A (-)-kolavenyl diphosphate synthase catalyzes the first step of salvinorin A biosynthesis in Salvia divinorum.
Journal of experimental botany February 1, 2017 Xiaoyue Chen, Anna Berim, Franck E Dayan et al.
Salvia divinorum (Lamiaceae) is an annual herb used by indigenous cultures of Mexico for medicinal and ritual purposes. The biosynthesis of salvinorin A, its major bioactive neo-clerodane diterpenoid, remains virtually unknown. This investigation aimed to identify the enzyme that catalyzes the first reaction of salvinorin A biosynthesis, the formation of (-)-kolavenyl diphosphate [(-)-KPP],...
DOI: 10.1093/jxb/erw493 (opens in new tab)
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Salvia divinorum
–-kolavenol
–-kolavenyl diphosphate
Diterpenoid diversification
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