Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway.
Phytochemistry July 1, 2007 Lukasz Kutrzeba, Franck E Dayan, J'Lynn Howell et al. 45 citations
Salvinorin A, a neoclerodane diterpenoid, isolated from the Mexican hallucinogenic plant Salvia divinorum, is a potent kappa-opioid receptor agonist. Its biosynthetic route was studied by NMR and HR-ESI-MS analysis of the products of the incorporation of [1-(13)C]-glucose, [Me-(13)C]-methionine, and [1-(13)C;3,4-(2)H2]-1-deoxy-D-xylulose into its structure. While the use of cuttings and...