Nature
April 3, 2019
Romain Nardou, Eastman M. Lewis, Rebecca Rothhaas et al.
343 citations
A critical period is a developmental epoch during which the nervous system is expressly sensitive to specific environmental stimuli that are required for proper circuit organization and learning. Mechanistic characterization of critical periods has revealed an important role for exuberant brain plasticity during early development, and for constraints that are imposed on these mechanisms as the...
Nature
April 24, 2016
Panos Zanos, Ruin Moaddel, Patrick J. Morris et al.
1,602 citations
Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months, to respond to these treatments, and many patients never attain sustained remission of their symptoms. The non-competitive, glutamatergic NMDAR (N-methyl-d-aspartate...
Nature
June 15, 2011
Anita E. Autry, M. Adachi, E. Nosyreva et al.
Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine, an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces fast-acting antidepressant responses in patients suffering from major depressive disorder, although the underlying mechanism is unclear. Depressed patients report the alleviation of major depressive disorder symptoms...
Nature
March 6, 2008
Javier González-Maeso, Rosalind L Ang, Tony Yuen et al.
The psychosis associated with schizophrenia is characterized by alterations in sensory processing and perception. Some antipsychotic drugs were identified by their high affinity for serotonin 5-HT2A receptors (2AR). Drugs that interact with metabotropic glutamate receptors (mGluR) also have potential for the treatment of schizophrenia. The effects of hallucinogenic drugs, such as psilocybin and...
Nature
May 1, 2004
Psychedelic drugs: the ups and downs of ecstasy.
Nature
December 11, 2003
Ilya Farber
The study of consciousness being rather broad, its more science-oriented practitioners quickly become adept at glancing through promising-looking new books to discern whether they partake a little too much of the ‘cosmic’. This isn’t usually difficult, but Susan Blackmore’s new book almost seems to have been intentionally designed to thwart such attempts at classification. Consciousness: An...
Nature
September 1, 2002
Olaf Blanke, Stéphanie Ortigue, Théodor Landis et al.
'Out-of-body' experiences (OBEs) are curious, usually brief sensations in which a person's consciousness seems to become detached from the body and take up a remote viewing position. Here we describe the repeated induction of this experience by focal electrical stimulation of the brain's right angular gyrus in a patient who was undergoing evaluation for epilepsy treatment. Stimulation at this...
Nature
August 31, 1995
G Bottini, E Paulesu, R Sterzi et al.
Lack of awareness of touch associated with brain damage may transiently recover after stimulation of the vestibular system. We used positron emission tomographic regional cerebral blood flow measurements to study the neurophysiological effect of vestibular stimulation on touch imperception in a subject with a right brain lesion. We tested the hypothesis that the vestibular system aids conscious...
Nature
April 1, 1971
Mirjana Randić, Ante L. Padjen
27 citations
Thin titanium films have been bombarded with low energy (350 eV) deuterium ions at high current density (0.2-0.4 mA.cm2) to investigate the reported occurrence of nuclear reactions at ambient temperatures in deuterium charged metals. A silicon charged particle detector was used to search for charged particles produced by such reactions. Evidence is reported for the detection of hydrogen...
Nature
June 13, 1970
D. W. Straughan
Psychotomimetic Drugs Proceedings of a Workshop organized by the Pharmacology Section, Psychopharmacology Research Branch, National Institute of Mental Health, held at the University of California, Irvine, on January 25–26, 1969. Edited by Daniel H. Efron (Workshop Series of Pharmacology Section, National Institute of Mental Health, No. 4.) Pp. 365. (Raven Press: New York; North-Holland:...
Nature
May 16, 1970
John Smythies, J. Beaton, F. Benington et al.
IN attempts to work out possible mechanisms of action of the hallucinogenic drugs, it would be helpful to know which chemical groups modify their activity. In the methoxylated amphetamines, some methoxy groups may act as electrostatic binding sites and some may effect the shape and energy distribution of the π cloud. It may also be important to know whether the amino group is necessary for...
Nature
May 16, 1970
Sungzong Kang, Jack Peter Green
THE actions of hallucinogenic agents have been correlated with Hückel molecular orbital calculations of the π-elections^1 and with fluorescent properties^2. The Hückel correlations on three methoxylated amphetamines indicated that hallucinogenic activity correlated with energy of the highest occupied molecular orbital^1.
Nature
1964
N. J. Giarman
This Special Issue of Neuropharmacology on psychedelics provides a timely and comprehensive update on progress following the previous Neuropharmacology Special Issue “ Psychedelics: New Doors, Altered Perceptions ” . Remarkable advances have been made in basic and clinical research on psychedelics in the five years since 2018. It is partly based on the seminar series focused on psilocybin...