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NPJ digital medicine

ISSN 2398-6352

3 papers in the library · 21 citations · publishing 2025-2026

Papers

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Alpha and theta audiovisual interventions in a reflective chamber demonstrate acute effects on stress and burnout.

NPJ digital medicine March 28, 2026 Aidan Cone, Sam Zuzick, Tiffany Durinski et al.

Escalating stress prevalence, particularly among essential service personnel whose cognitive compromise threatens public welfare, necessitates rapid, accessible non-pharmacological interventions. Individuals who struggle with endogenous cultivation of beneficial neuropsychological states may benefit from passive exogenous stimulation. This uncontrolled exploratory investigation (n = 74)...

Explainable AI-driven precision clinical trial enrichment: demonstration of the NetraAI platform with a phase II depression trial.

NPJ digital medicine December 8, 2025 Joseph Geraci, Bessi Qorri, Mike Tsay et al.

Clinical trial failures are frequently driven by patient heterogeneity and limited sample sizes that obscure treatment effects by diluting statistical power. We introduce NetraAI, a novel explainable artificial intelligence (AI) platform that integrates dynamical-systems modeling, evolutionary long-range memory feature selection, and large-language model (LLM)-generated insights, to discover...

Digital twin brain simulator for real-time consciousness monitoring and virtual intervention using primate electrocorticogram data.

NPJ digital medicine February 10, 2025 Yuta Takahashi, Hayato Idei, Misako Komatsu et al. 21 citations

At the forefront of bridging computational brain modeling with personalized medicine, this study introduces a novel, real-time, electrocorticogram (ECoG) simulator, based on the digital twin brain concept. Utilizing advanced data assimilation techniques, specifically a Variational Bayesian Recurrent Neural Network model with hierarchical latent units, the simulator dynamically predicts ECoG...