Background/Objectives: Anxiety disorders (ADs) affect up to 20% of mothers in the postpartum period, characterized by psychological symptoms (e.g., emotion dysregulation; ER) and physical symptoms (e.g., disrupted bodily awareness). Although Cognitive Behavioural Therapy effectively reduces anxiety and mood symptoms, it shows limited efficacy in addressing ER difficulties and rarely targets...
Background/Objectives: Emotion dysregulation is central to many psychiatric disorders. Laboratory-based tasks designed to assess emotion processing and regulation often rely on standardized affective stimuli whose ecological validity remains unclear. We contextualize this study in our broader research program of neurophenomenological reflection of standard paradigms in experimental cognitive...
Background/Objectives: This systematic review summarizes the evidence regarding potential mechanisms underlying the relationship between spiritual practices and cognitive health in adults. The review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Methods: An extensive search of six electronic databases (i.e., PubMed, PsycINFO,...
The past two decades have seen the reemergence of research investigating the therapeutic potential of psychedelic drugs across neuropsychiatric illnesses. One condition, alcohol use disorder (AUD), is of relevance given the broad public health implications and both limited effectiveness and attrition associated with currently available treatments. While emerging research has suggested that the...
Background: Substance use disorders (SUDs) are highly prevalent, affecting over 48.5 million Americans. Available treatments for SUD remain insufficient, and many patients do not respond to existing interventions despite adequate adherence to treatments. While novel therapies for SUD are urgently needed, the use of psychedelic drugs for the treatment of SUDs has shown promise. Objectives: This...
Background: Synthetic cannabinoid receptor agonists (SCRAs, commercially known as "Spice") have become a leading cause of substance-induced psychosis worldwide. These compounds show strong associations not only with acute psychotic episodes but also, in a subset of patients, with persistent or relapsing psychotic disorders, patterns that raise concern about progression to schizophrenia. Yet...
Addiction remains a persistent public health crisis, marked by poor treatment retention and limited pharmacotherapy options. Emerging treatments, such as psychedelic-assisted psychotherapy and neuromodulation, offer promising avenues for circuit-level interventions in behavioral addictions. This narrative review synthesizes the current landscape of psychedelic compounds and neuromodulation...
Indolethylamine N-methyltransferase (INMT) is a Class 1 methyltransferase responsible for N-methylation of various endogenous and exogenous compounds, including tryptamine, serotonin, and dopamine. This review aims to provide a comprehensive overview of the biological and therapeutic relevance of INMT, emphasizing the human isoform (hINMT), highlighting its structural characteristics, disease...
Approximately one-third of cancer survivors report a need for professional help to cope with Fear of Cancer Recurrence (FCR). In the REMOTE trial, we aim to investigate the efficacy of two internet-based mind-body techniques to address this currently unmet medical need. Cancer survivors, screened using the Cancer Worry Scale (CWS), are randomly assigned to one of the three study groups: (1)...
Brain SciencesAugust 21, 2025Dean Bilenker, Nicole M. Avena2 citations
Recent advances in psychedelic research have renewed interest in their therapeutic potential for psychiatric disorders characterized by cognitive and behavioral rigidity. This review examines the rationale for using serotonergic psychedelics—particularly 5-HT2A receptor agonists such as psilocybin—in the treatment of eating disorders (EDs), including anorexia nervosa (AN), bulimia nervosa (BN),...
Lucid dreaming (LD), during which the dreamer becomes aware of the dream state, offers a unique opportunity for a variety of applications, including motor practice, personal well-being, and nightmare therapy. However, these applications largely depend on the dreamer's ability to control their dreams. While LD research has traditionally focused on induction techniques to increase dream...
Background: The brain is never truly at rest. Even in the absence of external tasks, it remains active, continuously organizing itself into large-scale resting-state networks involved in shaping our internal thoughts and experiences. Understanding the networks' structure and dynamics is key to uncovering how the brain functions as a whole. While previous studies have mapped resting-state...
Brain SciencesJuly 9, 2025Evgenii Gusev, Alexey Sarapultsev, Maria Komelkova
Consciousness remains one of the most critical yet least understood functions of the brain, not only in humans but also in certain highly organized animal species. In this review, we propose treating consciousness as an emergent, goal-directed informational system organized by the subjective "self" as an active system-forming factor. We present an integrative theoretical-systems framework in...
In this conceptual review, we explore how alterations in the configuration and expression of the three core aspects of experiential Selfhood-'Self,' 'Me', and 'I'-both reflect and shape an individual's susceptibility to neuropsychopathology. Drawing on empirical neurophenomenological evidence and theoretical insights, we examine a range of psychiatric and neurological disorders through the lens...
Background: Dementia is a global condition affecting over 55 million people. Since there is no treatment, non-pharmacological interventions aim to delay its progression in a safe and cost-effective way. The extant literature suggests that Positive Psychology Interventions (PPIs) can probably be effective for this purpose. The systematic review aims to assess the effectiveness of PPIs as...
Brain SciencesMay 26, 2025Charles Palmer, Ally T Ferber, Brian D Greenwald4 citations
Background: This narrative review explores psilocybin’s potential use as a therapeutic agent in patients with traumatic brain injury (TBI). Methods: We engaged in a search of PubMed, ScienceDirect, and Cochrane’s databases for information on the effects of psilocybin. We also reviewed articles where psilocybin was used in patients with TBI. Articles from 2000–2025 were included. Results: A...
A unified theory of emotion and motivation is updated in which motivational states are states in which instrumental goal-directed actions are performed to obtain anticipated rewards or avoid punishers, and emotional states are states that are elicited when the (conditioned or unconditioned) instrumental reward or punisher is or is not received. This advances our understanding of emotion and...
Disorders of consciousness (DOCs) are a dynamic and challenging field, presenting significant difficulties for clinicians and neurorehabilitation specialists due to the lack of reliable assessment methods and effective intervention strategies [...].
Background: "Chemsex" involves the intake of a range of drugs (e.g., synthetic cathinones, gamma-hydroxybutyric acid/gamma-butyrolactone (GHB/GBL), ketamine, methamphetamine, "poppers", type V phosphodiesterase (PDE) inhibitors, MDMA/ecstasy, cocaine, cannabis, and occasionally a few other molecules as well, to enhance and prolong sexual experiences. This paper aims to provide an overview of...
BACKGROUND: The sense of agency (SoA)-the subjective experience of controlling one's own actions and their consequences-is a fundamental aspect of human cognition, volition, and motor control. Understanding how the SoA arises and is disrupted in neuropsychiatric disorders has significant implications for human-machine interface (HMI) design for neurorehabilitation. Traditional cognitive models...
Objectives: Prolonged disorders of consciousness (DoC) present complex diagnostic and therapeutic challenges. This study aimed to evaluate the accuracy of two ChatGPT models (ChatGPT 4o and ChatGPT o1) in answering questions about prolonged DoC, framed as if they were posed by a patient's relative. Secondary objectives included comparing performance across languages (English vs. Italian) and...
Disorder of consciousness (DoC) poses diagnostic challenges due to behavioral assessment limitations. This study evaluates the spectral exponent (SE)-a neurophysiological biomarker quantifying the decay slope of electroencephalography (EEG) aperiodic activity-as an objective tool for consciousness stratification and clinical behavior scores correlation. The study involved 15 DoC patients, nine...
Brain SciencesMarch 20, 2025Gilberto Galindo-Aldana, Luis Arturo Montoya-Rivera, Jose Jaime Esqueda-Elizondo et al.3 citations
Background. Mindfulness-based interventions (MBIs) have emerged as an alternative intervention for symptoms of psychological and psychiatric conditions, such as depression, anxiety, and emotional discomfort. Over the last ten years, MBIs have established a growing body of evidence that shows cognitive and neurophysiological benefits. Depression and anxiety are conditions with a high prevalence...
Background/Objectives: Non-response to initial treatment options for major depressive disorder (MDD) is a common clinical challenge with profound deleterious impacts for affected patients. Few treatments have received regulatory approval for treatment-resistant depression (TRD). Methods: A systematic search of United States and European Union clinical trials registries was conducted to identify...
Background: Psychedelics are increasingly recognized as a promising and innovative treatment strategy for several mental disorders. However, there is still a lively controversy in the medical community as regards the rationale of their employment, specifically their indications and potential dangers. Methods: A comprehensive literature search on “MEDLINE/PubMed” and “Web of Science” was...