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Curr Biol

ISSN 0960-9822; 1879-0445;

5 papers in the library · 892 citations · publishing 1996-2022

Papers

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Psychedelics.

Curr Biol 2022 Benjamin Kelmendi, Alfred P. Kaye, Christopher Pittenger et al. 115 citations

Psychedelics are compounds that alter consciousness by acting on serotonin receptors in the brain. The term 'psychedelic', from the Greek for mind manifesting, refers to the drugs' subjective effects and was first proposed by Humphry Osmond in 1956. Other terms have been used to emphasize different aspects of the psychological experiences produced by various related compounds, including...

Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD.

Curr Biol September 27, 2018 Gustavo Deco, Josephine Cruzat, Joana Cabral et al. 246 citations

Understanding the underlying mechanisms of the human brain in health and disease will require models with necessary and sufficient details to explain how function emerges from the underlying anatomy and is shaped by neuromodulation. Here, we provide such a detailed causal explanation using a whole-brain model integrating multimodal imaging in healthy human participants undergoing manipulation...

Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution.

Curr Biol April 13, 2016 Enzo Tagliazucchi, Leor Roseman, Mendel Kaelen et al. 531 citations

Lysergic acid diethylamide (LSD) is a non-selective serotonin-receptor agonist that was first synthesized in 1938 and identified as (potently) psychoactive in 1943. Psychedelics have been used by indigenous cultures for millennia [1]; however, because of LSD's unique potency and the timing of its discovery (coinciding with a period of major discovery in psychopharmacology), it is generally...