Journal of visualized experiments : JoVE
May 29, 2026
Tommi Kiiso, Paula Partanen, Keyrstin Jacobs et al.
The default mode network (DMN) is a central, large-scale brain network implicated in a range of cognitive functions and neuropsychiatric disorders, such as major depressive disorder (MDD). Studying the DMN's complex dynamics in animal models provides invaluable insights into its function in both healthy and pathological states. However, performing stable, long-term, large-scale...
Journal of visualized experiments : JoVE
January 9, 2026
Tingjun Zhang, Shujuan Yan, Hui Wang et al.
While perioperative esketamine use has grown increasingly prevalent, evidence supporting its efficacy and safety in elderly patients undergoing laparoscopic prostate cancer surgery remains limited. This retrospective study evaluated intravenous esketamine's performance in this population by analyzing 186 elderly patients treated between 2021 and 2024, divided into a control group (n = 91;...
Journal of visualized experiments : JoVE
August 1, 2025
Kwang-Mook Jung, Alex Mabou Tagne, Heidi C Avalos et al.
Δ9-tetrahydrocannabinol (THC) is responsible for the intoxicating (psychotropic) effects of cannabis and cannabis-derived products currently available in the legal and illegal markets. The psychotropic effects of THC are produced via activation of CB1 cannabinoid receptors in the brain, which are normally engaged by endogenous cannabinoid (endocannabinoid) substances. Outside the brain, THC...
Journal of visualized experiments : JoVE
March 8, 2019
Mai Minoura, Iori Tani, Takahiro Ishii et al.
How is our bodily self-consciousness acquired, and how does it affect cognition? To investigate this, we conducted an experiment using the squeeze machine, a device that provides pressure along the length of the user's whole body. The squeeze machine is used to help autistic people relax. The inventor of the machine, Dr. Temple Grandin says that the squeeze machine, beyond bringing her...
Journal of visualized experiments : JoVE
January 13, 2018
Andria Pelentritou, Levin Kuhlmann, John Cormack et al.
Anesthesia arguably provides one of the only systematic ways to study the neural correlates of global consciousness/unconsciousness. However to date most neuroimaging or neurophysiological investigations in humans have been confined to the study of γ-Amino-Butyric-Acid-(GABA)-receptor-agonist-based anesthetics, while the effects of dissociative...
Journal of visualized experiments : JoVE
December 28, 2010
Mark A Halko, Mark C Eldaief, Jared C Horvath et al.
The default mode network is a group of brain regions that are active when an individual is not focused on the outside world and the brain is at "wakeful rest." It is thought the default mode network corresponds to self-referential or "internal mentation". It has been hypothesized that, in humans, activity within the default mode network is correlated with certain pathologies (for instance,...