A subset of patients in a minimally conscious state show improved behavioral responsiveness after transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex, while those who are unresponsive show limited benefit. Among 131 patients, 32% of minimally conscious patients responded to tDCS, compared to 10% of unresponsive patients. A regression model using baseline diagnosis, Coma Recovery Scale-Revised Index, age, sex, and time since injury correctly identified responders 77% of the time. Patients in a minimally conscious state with better cognitive profiles and longer time since injury appear to respond better to tDCS, suggesting they are better candidates for this treatment.
Patients with disorders of consciousness, such as those in a minimally conscious state or with unresponsive wakefulness syndrome, often face misdiagnosis because standard assessments rely on motor responses that can be absent due to cognitive-motor dissociation. This study tested whether heart rate variability (HRV) responses to personalized videos of acquaintances differ from responses to videos of strangers. In 17 healthy subjects, HRV measures significantly differed between personalized and non-personalized stimuli, but 11 patients with disorders of consciousness showed no such differences. Significant differences in HRV measures also emerged between the two groups. These findings suggest impaired emotional processing in patients with disorders of consciousness, and that integrating HRV measures may improve diagnosis.
A pilot randomized controlled trial tested the feasibility of three online-delivered mindfulness practices—visceral body scan, somatosensory body scan, and external (non-body) meditation—in 48 adults recruited from social networks. The retention rate was 66.20% and adherence to meditation practice was 56.53%. Acceptability and practice quality were moderate, and most participants reported no adverse effects. Preliminary effects emerged: the visceral body scan was linked to decreased attention to unpleasant bodily sensations, and both visceral and somatosensory body scans were associated with a decrease in dampening of positive emotions. The authors conclude that feasibility improvements are needed before larger-scale research.
A self-compassion meditation procedure using a virtual reality body swap illusion (the machine to be another system) was compared with a standard audio-only meditation in 16 participants. Both conditions increased positive qualities toward self/others, decreased negative qualities toward self, and improved awareness of mental events and bodily sensations immediately after practice, with no differences between groups. After two weeks of home practice, both groups showed similar meditation frequency and increases in self-care behaviors, though clinical self-care behaviors were significantly higher in the VR group. Lower visual and cutaneous imagery ability moderated the VR condition's effectiveness in increasing adherence, suggesting embodied VR may help those who struggle with mental imagery in compassion-based interventions.