Tiziana Pisano

2 papers in the library · publishing 2023-2026

Papers

Introducing the ASI-NPI project: preliminary analysis of a study exploring the role of cannabis, salience alterations and youth in determining psychotic symptoms severity

Research Square November 20, 2023 Ottone Baccaredda Boy, Giuseppe Pierpaolo Merola, Andrea Patti et al.

Adolescents reported more severe psychotic symptoms on the Positive and Negative Syndrome Scale than adults, while no significant difference was found in cannabis exposure or Aberrant Salience Inventory scores. A hierarchical pattern emerged among adult subgroups, with psychotic patients scoring higher than other psychiatric and neurological patients. The findings suggest that aberrant salience, and to a lesser degree cannabis use, may contribute to psychotic symptom severity, particularly during more at-risk developmental phases. The role of cannabis in this relationship remains unclear.

DOI: 10.21203/rs.3.rs-3615804/v1 Full text Cannabis Psychopathology Salience neuroscience Psychosis +4

Disrupted Emergent Properties of the Brain in Schizophrenia: Insight From Integrated Information Decomposition of Resting State fMRI.

Brain and Behavior April 1, 2026 Livio Tarchi, Lorenzo Lasagni, Leonardo Ubaldi et al.

Integrated information decomposition of resting-state fMRI data from 72 people with schizophrenia and 74 healthy controls revealed that redundancy in brain connectivity was positively correlated with IQ across both groups. Within patients, information metrics were positively correlated with stereotyped thinking, preoccupation, and positive symptoms. Diagnostic accuracy reached 84.93% balanced accuracy (area under the curve = 92.30%) using redundancy. These preliminary findings suggest that information metrics may offer clinically relevant, interpretable biomarkers for schizophrenia.

DOI: 10.1002/brb3.71352 Full text Computational psychiatry Integrated information theory Psychosis Resting State FMRI