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Cheryl M Corcoran

2 papers in the library · 22 citations · publishing 2022-2023

Papers

Emergence of Language Related to Self-experience and Agency in Autobiographical Narratives of Individuals With Schizophrenia.

Schizophrenia Bulletin March 15, 2023 Chi C Chan, Raquel Norel, Carla Agurto et al. 22 citations

Disturbances in self-experience—the sense of being the subject of one's own experiences and actions, and of being distinct from others—are central to schizophrenia. Traditionally assessed by manual interview rating, this study used natural language processing to analyze autobiographical narratives from 167 patients with schizophrenia or schizoaffective disorder and 90 healthy controls, totaling 490,000 words. Topics related to self-experience and agency were significantly more expressed in patients than controls and were decoupled from emotional tone, semantic coherence, and burden-related concepts. A classifier trained on these features discriminated patients from controls with an AUC of 0.80. These findings demonstrate that NLP can automatically detect higher-order metacognitive aspects of self-experience without explicit probing.

Smoked Cannabis Effects in Cannabis Users at Clinical High-Risk for Psychosis: A Further Investigation of Cognition and Reward

Cannabis February 22, 2022 Sean P Madden, John G Keilp, Olivia Wu et al.

Cannabis acutely worsened cognitive control and produced more aversive intoxication in cannabis users at clinical high-risk for psychosis, but not in psychiatrically-healthy cannabis users. Six high-risk and six healthy users smoked either active (5.5% THC) or placebo cannabis under double-blind conditions. High-risk participants showed decreased response inhibition and aversive intoxication after active cannabis, along with changes in psychomotor speed and cannabis-related attentional bias. No such effects appeared in healthy users. The findings provide preliminary evidence of a deleterious cognitive and reward-related response to cannabis in individuals with preexisting psychosis risk.