The effect of medial prefrontal cortex inactivation on psychedelic-mediated emergence from anesthesia
Physiology May 1, 2025 Andres Villegas Calderon, Emma R. Huels, Amanda Nelson et al.
Serotonergic psychedelics are being explored as therapeutic agents for mental health disorders and have also been shown to promote wakefulness. In a recently completed study (reported as preliminary findings), we showed that intravenous administration of 2,5-Dimethoxy-4-iodoamphetamine (DOI), a classic serotonergic psychedelic, can induce wakefulness and reverse the state of anesthesia produced...