We show that both pharmacological and non-pharmacological treatments of depression activate TrkB receptors—a well-established target of antidepressants—by inducing a physiological response coupled to sedation. Several rapid-acting antidepressants trigger TrkB signaling by evoking a state associated with electroencephalographic slow-wave activity, behavioral immobility, reduced cerebral glucose...
abstract:Received wisdom has it that psychologists and philosophers came to mistrust consciousness for largely behaviorist reasons. But by the time John Watson had published his behaviorist manifesto in 1913, a wider revolt against consciousness was already underway. I focus on William James, an earlier influential source of unease about consciousness. James's mistrust of consciousness grew out...