Depression treatment response to ketamine: sex-specific role of interleukin-8, but not other inflammatory markers
Translational Psychiatry March 21, 2021 Jennifer L. Kruse, Megha M Vasavada, Richard Olmstead et al. 47 citations
Abstract Inflammation plays a role in depression pathophysiology and treatment response, with effects varying by sex and therapeutic modality. Lower levels of interleukin(IL)-8 predict depression response to antidepressant medication and to electroconvulsive therapy (ECT), although ECT effects are specific to females. Whether IL-8 predicts depression response to ketamine and in a sex-specific...