Gerhard Hellemann

2 papers in the library · 65 citations · publishing 2021-2022

Papers

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Anterior default mode network and posterior insular connectivity is predictive of depressive symptom reduction following serial ketamine infusion.

Psychological Medicine September 1, 2022 Benjamin Wade, Joana R Loureiro, Ashish K Sahib et al. 18 citations

Ketamine is a rapidly-acting antidepressant treatment with robust response rates. Previous studies have reported that serial ketamine therapy modulates resting state functional connectivity in several large-scale networks, though it remains unknown whether variations in brain structure, function, and connectivity impact subsequent treatment success. We used a data-driven approach to determine...

DOI: 10.1017/s0033291722001313 Full text Default mode network Major depressive disorder Functional connectivity Machine learning +1

Depression treatment response to ketamine: sex-specific role of interleukin-8, but not other inflammatory markers

Translational Psychiatry March 21, 2021 Jennifer L. Kruse, Megha M Vasavada, Richard Olmstead et al. 47 citations

Abstract Inflammation plays a role in depression pathophysiology and treatment response, with effects varying by sex and therapeutic modality. Lower levels of interleukin(IL)-8 predict depression response to antidepressant medication and to electroconvulsive therapy (ECT), although ECT effects are specific to females. Whether IL-8 predicts depression response to ketamine and in a sex-specific...

DOI: 10.1038/s41398-021-01268-z Full text