Nicholas Murphy

2 papers in the library · publishing 2021-2026

Papers

Sort Most recent Most cited

High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?

Translational Psychiatry July 4, 2026 Krisha Shah, Rubén Herzog, Alan C. Swann et al.

Ketamine is a fast-acting intervention for treatment-resistant depression (TRD), yet only a subset of patients show robust clinical response, and the underlying neural mechanisms remain unclear. High-order interactions (HOI) derived from multivariate information theory provide a framework for examining nonlinear dependencies among brain regions beyond pairwise connectivity. One such metric, the...

DOI: 10.1038/s41398-026-04212-1 Full text Ketamine Dissociative Depression economics Cohort +3

Identification of an Optimal Dose of Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Bayesian Adaptive Randomization Trial

Neuropsychopharmacology November 27, 2021 Marijn Lijffijt, Nicholas Murphy, Sidra Iqbal et al.

Evidence supporting specific therapies for late-life treatment-resistant depression (LL-TRD) is necessary. This study used Bayesian adaptive randomization to determine the optimal dose for the probability of treatment response (≥50% improvement from baseline on the Montgomery-Åsberg Depression Rating Scale) 7 days after a 40 min intravenous (IV) infusion of ketamine 0.1 mg/kg (KET 0.1), 0.25...

DOI: 10.1038/s41386-021-01242-9 Full text