High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?
Translational Psychiatry July 4, 2026 Krisha Shah, Rubén Herzog, Alan C. Swann et al.
Ketamine is a fast-acting intervention for treatment-resistant depression (TRD), yet only a subset of patients show robust clinical response, and the underlying neural mechanisms remain unclear. High-order interactions (HOI) derived from multivariate information theory provide a framework for examining nonlinear dependencies among brain regions beyond pairwise connectivity. One such metric, the...
DOI: 10.1038/s41398-026-04212-1 (opens in new tab)
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Ketamine
Dissociative
Depression economics
Cohort
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