Brittany O’brien

2 papers in the library · publishing 2019-2026

Papers

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High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?

Translational Psychiatry July 4, 2026 Krisha Shah, Rubén Herzog, Alan C. Swann et al.

Ketamine is a fast-acting intervention for treatment-resistant depression (TRD), yet only a subset of patients show robust clinical response, and the underlying neural mechanisms remain unclear. High-order interactions (HOI) derived from multivariate information theory provide a framework for examining nonlinear dependencies among brain regions beyond pairwise connectivity. One such metric, the...

DOI: 10.1038/s41398-026-04212-1 Full text Ketamine Dissociative Depression economics Cohort +3

The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression

Pharmaceuticals September 11, 2019 Brittany O’brien, Marijn Lijffijt, Allison Wells et al.

Childhood maltreatment is associated with a poor treatment response to conventional antidepressants and increased risk for treatment-resistant depression (TRD). The N-methyl-D-aspartate receptor (NDMAR) antagonist ketamine has been shown to rapidly improve symptoms of depression in patients with TRD. It is unknown if childhood maltreatment could influence ketamine’s treatment response. We...

DOI: 10.3390/ph12030133