High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?
Translational Psychiatry July 4, 2026 Krisha Shah, Rubén Herzog, Alan C. Swann et al.
Ketamine is a fast-acting intervention for treatment-resistant depression (TRD), yet only a subset of patients show robust clinical response, and the underlying neural mechanisms remain unclear. High-order interactions (HOI) derived from multivariate information theory provide a framework for examining nonlinear dependencies among brain regions beyond pairwise connectivity. One such metric, the...