The Neuroscientist
December 26, 2025
Kallol Bera, Loren L. Looger, Alex Proekt et al.
5 citations
Ketamine is a unique anesthetic agent that induces dissociative anesthesia, characterized by perceptual detachment, analgesia, and altered states of consciousness. Beyond its widespread use in anesthesia, subhypnotic ketamine dosing has emerged as a rapid-acting antidepressant and a valuable model for probing the neural mechanisms underlying consciousness and neuropsychiatric disorders. At the...
Journal of Neuroscience
May 14, 2025
Diego G Dávila, Andrew McKinstry-Wu, Max B Kelz et al.
5 citations
During wakefulness, external stimuli elicit conscious experiences. In contrast, dreams and drug-induced dissociated states are characterized by vivid internally generated conscious experiences and reduced ability to perceive external stimuli. Understanding the physiological distinctions between normal wakefulness and dissociated states may therefore disambiguate signatures of responsiveness to...
Cell Reports
April 23, 2024
Adeeti Aggarwal, Jennifer Luo, Helen Chung et al.
17 citations
The relationship between sensory stimuli and perceptions is brain-state dependent: in wakefulness, suprathreshold stimuli evoke perceptions; under anesthesia, perceptions are abolished; and during dreaming and in dissociated states, percepts are internally generated. Here, we exploit this state dependence to identify brain activity associated with internally generated or stimulus-evoked...
Journal of Neuroscience
July 29, 2015
Guillermo Solovey, Leandro M Alonso, Toru Yanagawa et al.
What aspects of neuronal activity distinguish the conscious from the unconscious brain? This has been a subject of intense interest and debate since the early days of neurophysiology. However, as any practicing anesthesiologist can attest, it is currently not possible to reliably distinguish a conscious state from an unconscious one on the basis of brain activity. Here we approach this problem...