Adam R Pines

2 papers in the library · 15 citations · publishing 2023-2026

Papers

Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results.

Neuroscience and Biobehavioral Reviews November 1, 2023 Sophia Linguiti, Jacob W Vogel, Valerie J Sydnor et al. 15 citations

A systematic review of 91 fMRI studies on acute psychedelic effects found substantial methodological heterogeneity. Only 51 unique samples were used across the 91 papers, and 54% of studies did not meet current standards for correcting Type I errors or controlling motion artifacts. Psilocybin and LSD consistently modulated connectivity along the sensorimotor-association cortical axis. Ketamine consistently increased activation in the dorsomedial prefrontal cortex. The review calls for future adoption of pre-registration, standardized processing and statistical testing, and data sharing to improve rigor.

DOI: 10.1016/j.neubiorev.2023.105421 Full text Ketamine LSD MDMA Psilocybin +8

Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice.

Proceedings of the National Academy of Sciences of the United States of America June 16, 2026 Adam R Pines, Xue Zhang, John Kochalka et al.

Psychedelic drugs consistently reduce the strength and bottom-up direction of signal flow within the brain's default mode network, according to analyses of four independent datasets spanning humans and mice and three different psychedelic compounds (MDMA, psilocybin, and LSD). This attenuation of cortical propagations is not explained by data quality or previously known effects of psychedelics and is uniquely tied to self-reported outcomes. The findings clarify how psychedelics alter macroscale hierarchical processing in the brain.

DOI: 10.1073/pnas.2522000123 Full text Default mode network Cortical propagations Hierarchical processing Neuroimaging +1