Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice.
Proceedings of the National Academy of Sciences of the United States of America June 16, 2026 Adam R Pines, Xue Zhang, John Kochalka et al.
Psychedelic drugs are poised to become mainstream treatments, yet we lack a circuit-level account of how they reshape brain activity. Emerging evidence suggests that multiple psychedelic compounds modulate activity in the brain's default mode network (DMN), often interpreted as either increased or decreased bottom-up hierarchical processing. Most imaging studies, however, quantify activity as...