BACKGROUND: Current treatments for obsessive-compulsive disorder (OCD), including serotonin reuptake inhibitors and cognitive-behavioral therapy, are often insufficient. Psilocybin, a 5HT2a agonist psychedelic, has shown promise for treating OCD, but rigorous evidence is still needed. AIMS: This randomized clinical trial evaluated safety, tolerability, and benefit of multiple psilocybin doses...
Systematic focus training is increasingly recognized for its therapeutic benefits, with equanimity, the ability to maintain an open and accepting attitude towards all experience, identified as a critical mechanism for improving well-being. Physiologically, experienced meditators demonstrate reduced activity in the posterior cingulate cortex (PCC), a hub of the default mode network (DMN), and...
Emerging research suggests some of the most profound meditation-induced psychological transformations require mastery of mental skills that enable access to advanced meditative states, stages, and endpoints. Such development, however, often demands years of sustained practice and expert guidance. Transcranial focused ultrasound (tFUS) offers a novel means of potentially supporting meditative...