Microdosing and drug development: past, present and future
Expert Opinion on Drug Metabolism & Toxicology April 4, 2013 Graham Lappin, Robert J. Noveck, Tal Burt 97 citations
INTRODUCTION: Microdosing is an approach to early drug development where exploratory pharmacokinetic data are acquired in humans using inherently safe sub-pharmacologic doses of drug. The first publication of microdose data was 10 years ago and this review comprehensively explores the microdose concept from conception, over the past decade, up until the current date. AREAS COVERED: The authors...