JAMA Network OpenSeptember 1, 2022Sangeeta P Joshi, An-Kwok Ian Wong, Amanda Brucker et al.
Health care workers (HCWs) have been experiencing substantial stress and burnout, and evidence-based mitigation strategies are needed. Transcendental Meditation (TM) is a mantra meditation practice with potential efficacy in reducing stress. To assess the efficacy of TM practice in reducing stress among HCWs over a 3-month period. This single-center open-label randomized clinical trial was...
Intraarterial microdosing (IAM) is a novel drug development approach combining intraarterial drug delivery and microdosing. We aimed to demonstrate that IAM leads to target exposure similar to that of systemic full-dose administration but with minimal systemic exposure. IAM could enable the safe, inexpensive, and early study of novel drugs at the first-in-human stage and the study of...