Dose-Response Study of N,N-Dimethyltryptamine in Humans
Archives of General Psychiatry February 1, 1994 Ruck J. Strassman 454 citations
BACKGROUND: Validation of animal models of hallucinogenic drugs' subjective effects requires human data. Previous human studies used varied groups of subjects and assessment methods. Rating scales for hallucinogen effects emphasized psychodynamic principles or the drugs' dysphoric properties. We describe the subjective effects of graded doses of N,N-dimethyltryptamine (DMT), an endogenous...