In less than 50 years the number of MDMA (3,4-Methylenedioxymethamphetamine or Ecstasy) users in the United States has gone from zero to nearly three million.For all of its popularity, very little is known about MDMA's probable mechanism of action, or the mechanisms by which it causes death and disability.Even less is known about this drug's checkered past, including dangerous plans by various...
Experimental and clinical data indicate that 3,4-methylenedioxy-N-methylamphetamine (MDMA) abuse can produce significant cardiovascular toxicity. A mechanism may be a direct toxic effect of redox active metabolites of MDMA. To evaluate the effect of a single MDMA dose on cellular antioxidant defence system and to investigate the morphology in male albino rats, total glutathione (GSH), oxidised...