Cardiac oxidative stress determination and myocardial morphology after a single ecstasy (MDMA) administration in a rat model.
International Journal of Legal Medicine November 2008 Daniela Cerretani, Irene Riezzo, Anna Ida Fiaschi et al.
Experimental and clinical data indicate that 3,4-methylenedioxy-N-methylamphetamine (MDMA) abuse can produce significant cardiovascular toxicity. A mechanism may be a direct toxic effect of redox active metabolites of MDMA. To evaluate the effect of a single MDMA dose on cellular antioxidant defence system and to investigate the morphology in male albino rats, total glutathione (GSH), oxidised...