Molecular determinants for binding of methylenedioxytryptamines at 5-HT/LSD receptors
International Journal of Quantum Chemistry March 5, 1981 Patricia H. Reggio, Harel Weinstein, Roman Osman et al. 17 citations
In investigations of the molecular determinants for the recognition of drugs by a serotonin (5-HT) receptor in the brain, the commonality in the reactivity patterns of 5-HT congeners has been identified. On this basis a mechanistic hypothesis is proposed to explain the rank order of the affinity of drugs that bind to the receptor shared by 5-HT and LSD (the 5-HT/LSD receptor). This hypothesis...