Opposite alterations of 5HT2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile
Translational Psychiatry May 20, 2021 Rebeca Dı́ez-alarcia, Carolina Muguruza, Guadalupe Rivero et al. 27 citations
Abstract The status of serotonin 5HT 2A receptors (5HT 2A Rs) in schizophrenia has been controversial. In vivo positron emission tomography neuroimaging and in vitro post-mortem binding studies have reported conflicting results about 5HT 2A R density. Radiotracers bind different receptor conformations depending on their agonist, antagonist or inverse agonist properties. This study...
DOI: 10.1038/s41398-021-01430-7 (opens in new tab)
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Serotonin
Inverse agonist
Antipsychotic
Schizophrenia object-oriented programming
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