Treatment-Resistant Depression: Approaches to Treatment
Journal of Psychosocial Nursing and Mental Health Services August 30, 2021 Karan S Kverno, Emma Mangano 121 citations
Approximately 30% of people treated for a major depressive episode will not achieve remission after two or more treatment trials of first-line antidepressants and are considered to have treatment-resistant depression (TRD). Because the odds of remission decrease with every subsequent medication trial, it is important for clinicians to understand the characteristics and risk factors for TRD,...