Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry September 15, 2023 Roger S McIntyre, Mohammad Alsuwaidan, Bernhard T Baune et al. 712 citations
Treatment‐resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision‐making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a...