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Karan S Kverno

2 papers in the library · 121 citations · publishing 2021-2022

Papers

Treatment-Resistant Depression: Approaches to Treatment

Journal of Psychosocial Nursing and Mental Health Services August 30, 2021 Karan S Kverno, Emma Mangano 121 citations

About 30% of people treated for a major depressive episode do not achieve remission after two or more trials of first-line antidepressants, a condition known as treatment-resistant depression (TRD). Because the chance of remission declines with each additional medication trial, clinicians need to understand the characteristics, risk factors, and subtypes of major depressive disorder that are less responsive to standard treatments. This article reviews approved treatments for TRD, including esketamine, and the evidence for psilocybin and pramipexole. Although guidelines to help identify person-centered treatments are available, they remain limited in specificity.

DOI: 10.3928/02793695-20210816-01 (opens in new tab) Treatment-resistant depression Major depressive disorder Psychiatry Depression economics +6

Dextromethorphan: From Cough Suppressant to Antidepressant.

Journal of Psychosocial Nursing and Mental Health Services November 1, 2022 Karan S Kverno

Dextromethorphan (DXM) has been repurposed over seven decades: first as a cough suppressant, then combined with quinidine for pseudobulbar affect, and most recently formulated with bupropion for major depressive disorder. This article describes DXM's history and mechanisms of action for each use, highlighting the uniquely rapid action and safety profile of the oral dextromethorphan-bupropion antidepressant formulation.

DOI: 10.3928/02793695-20221005-02 (opens in new tab) Medicine Psychology