Neuropsychopharmacology
July 10, 2026
Christopher W. Thomas, Kayleigh S. Lamalfa, Tobias P. Whelan et al.
Anhedonia, the blunted responsiveness to previously rewarding stimuli, is a core symptom of several psychiatric disorders. Ketamine and psilocybin have shown promising evidence in ameliorating anhedonic symptoms in clinical trials. The Probabilistic Reward Task (PRT) was developed to objectively quantify reward responsiveness in clinical populations and laboratory animals. Here, the PRT was...
bioRxiv (Cold Spring Harbor Laboratory)
March 4, 2026
Matthew D. B. Claydon, Justyna K. Hinchcliffe, Julia M. Bartlett et al.
Abstract Psilocybin, a serotonergic psychedelic, can produce rapid and enduring antidepressant effects in patients with major depressive disorder (MDD)[1, 2], yet the neural mechanisms underlying these effects remain unclear. Negative affective biases are an important neuropsychological mechanism central to the development and perpetuation of MDD[3]. Using a translational rodent model, we...
Psychedelic Medicine
February 3, 2026
Anton T. Gregersen, Tobias P. Whelan, Caroline T. Golden et al.
2 citations
Introduction: Cognitive flexibility is essential for behavioral adaptation in response to environmental changes and is impaired in various neuropsychiatric disorders. The serotonergic psychedelic psilocybin has shown potential in enhancing cognitive flexibility, although with mixed results. In this study, we investigated the effects of psilocybin on cognitive flexibility in rats using a...
Mol Psychiatry
December 1, 2025
Ross J. Purple, Rahul Gupta, Christopher W. Thomas et al.
correction
In this article the author’s name Robin Carhart-Harris was incorrectly written as Robin Carhartt-Harris. The original article has been corrected.
Molecular Psychiatry
August 26, 2025
Ross J. Purple, Rahul Gupta, Christopher W. Thomas et al.
2 citations
Abstract We quantify cellular- and circuit-resolution neural network dynamics following therapeutically relevant doses of the psychedelic psilocybin. Using chronically implanted Neuropixels probes, we recorded local field potentials (LFP) alongside action potentials from hundreds of neurons spanning infralimbic, prelimbic and cingulate subregions of the medial prefrontal cortex of...
February 27, 2025
Anton T. Gregersen, Tobias P. Whelan, Caroline T. Golden et al.
preprint
IntroductionCognitive flexibility is essential for adapting behavior in response to environmental changes and is implicated in various neuropsychiatric disorders. Psilocybin, a serotonergic psychedelic, has shown potential in enhancing cognitive flexibility, though results are mixed. This study investigates the effects of psilocybin on cognitive flexibility using a three-choice visual reversal...
bioRxiv (Cold Spring Harbor Laboratory)
December 13, 2024
Ross J. Purple, Rekha Gupta, Christopher W. Thomas et al.
1 citation
preprint
SUMMARY We quantify cellular- and circuit-resolution neural network dynamics following therapeutically relevant doses of the psychedelic psilocybin. Using chronically implanted Neuropixels probes, we recorded local field potentials (LFP) alongside action potentials from hundreds of neurons spanning infralimbic, prelimbic and cingulate subregions of the medial prefrontal cortex of...
Scientific Reports
July 26, 2022
Caroline T. Golden, Paul Chadderton
45 citations
Abstract Psilocybin is a hallucinogenic compound that is showing promise in the ability to treat neurological conditions such as depression and post-traumatic stress disorder. There have been several investigations into the neural correlates of psilocybin administration using non-invasive methods, however, there has yet to be an invasive study of the mechanism of action in awake rodents. Using...
Spiral (Imperial College London)
December 1, 2016
Caroline T. Golden
The prefrontal cortex (PFC) plays a strong role in the execution of executive tasks such as working memory. It is thought to exert top-down control over sensory regions, and integrate information from both external stimuli, and internal computation, such as choice and expectation (1-3). The anterior cingulate cortex (ACC) is a region of the PFC known to receive strong projections from...