Hannah M. Kramer - The Consciousness Library

Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity

Neuropsychopharmacology November 12, 2025 Hannah M. Kramer, Meghan Hibicke, Jason W. Middleton et al. 7 citations

Activation of serotonin 2A (5-HT2A) receptors is thought to underly the long-lasting antidepressant effects of psychedelics such as psilocybin, but beyond that, the molecular and cellular mechanisms involved are not well understood. Recent preclinical studies using mice have primarily examined relatively short time points after psychedelic administration, which does not address the long-lasting...

DOI: 10.1038/s41386-025-02272-3 Full text Psilocybin Neuroplasticity Synaptic plasticity Serotonin +11

Psychedelic Research as a Career Path: A Roundtable Discussion with Early Career Researchers in the Field.

Psychedelic Med (New Rochelle) March 12, 2024 Jacob S. Aday, Natasha L. Mason, Bo Jarrett Wood et al.

Psychedelic MedicineAhead of Print Psychedelic Research as a Career Path: A Roundtable Discussion with Early Career Researchers in the FieldModerators: Jacob S. Aday, Natasha L. Mason, Participants: Bo Jarrett Wood, Hannah M. Kramer, Cynthia E. Ortiz, M. Frances Vest, Caroline Sagrera, and C. J. HealyModerators: Jacob S. Aday*Address correspondence to: Jacob S. Aday, PhD, Department of...

DOI: 10.1089/psymed.2023.0053 Full text Psychedelic science Psychedelic research Psychedelics Psychedelic studies +20

A Single Administration of Psilocybin Persistently Rescues Cognitive Deficits Caused by Adolescent Chronic Restraint Stress Without Long-Term Changes in Synaptic Protein Gene Expression in a Rat Experimental System with Translational Relevance to Depression.

Psychedelic medicine (New Rochelle, N.Y.) March 1, 2023 Meghan Hibicke, Hannah M. Kramer, Charles D. Nichols 25 citations

Psilocybin has shown long-lasting antidepressant effects in preclinical and clinical trials, but the mechanisms responsible are unclear. As both passive coping strategies and pattern separation deficits are characteristics of major depression, we used adult female rats subjected to adolescent chronic restraint stress (aCRS) to investigate the effects of psilocybin on forced swim test (FST) and...

DOI: 10.1089/psymed.2022.0012 Full text Depression Psilocybin Adolescent stress Pattern separation +8

Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression

ACS Chemical Neuroscience March 5, 2020 Meghan Hibicke, Alexus N. Landry, Hannah M. Kramer et al. 211 citations

Psilocybin shows efficacy to alleviate depression in human clinical trials for six or more months after only one or two treatments. Another hallucinogenic drug, esketamine, has recently been U.S. Food and Drug Administration (FDA)-approved as a rapid-acting antidepressant. The mechanistic basis for the antidepressant effects of psilocybin and ketamine appear to be conserved. The efficacy of...

DOI: 10.1021/acschemneuro.9b00493 Psilocybin Ketamine Lysergic acid diethylamide Serotonin +6

Papers

Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity

Psychedelic Research as a Career Path: A Roundtable Discussion with Early Career Researchers in the Field.

A Single Administration of Psilocybin Persistently Rescues Cognitive Deficits Caused by Adolescent Chronic Restraint Stress Without Long-Term Changes in Synaptic Protein Gene Expression in a Rat Experimental System with Translational Relevance to Depression.

Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression