The International Journal of Neuropsychopharmacology
September 1, 2026
N Hartman, D Ivkic, M C Dorczok et al.
Abstract Background Neuropsychiatric manifestations of Long COVID (LC) frequently include post-exertional malaise (Cheng et al., 2025), fatigue, cognitive dysfunction and impairment, sleep disturbances, post-traumatic stress, autonomic dysregulation, pain, inner tension, psychomotor retardation, aberrations in appetite and weight (Badenoch et al., 2022; O'Mahoney et al., 2025), showing...
Research Square
July 9, 2026
Samuel Westenhöfer, Yamina Ehrt, Barbora Provaznikova et al.
Abstract Background : Treatment-resistant depression (TRD) is associated with substantial clinical and socioeconomic burden. Intranasal esketamine has shown efficacy for TRD in clinical trials and real-world studies. However, evidence on optimal maintenance scheduling is limited. We therefore investigated whether two maintenance schedules differing in their inter-dose intervals were associated...
Therapeutic Advances in Psychopharmacology
2026
Manfred Klöbl, Thomas Liebe, Gregor Dörl et al.
Ketamine, a well-established antidepressant and dissociative anesthetic, is also used recreationally in the club and chemsex scene. Survey and qualitative data suggest that while ketamine facilitates chemsex encounters, it diminishes the intensity of the sexual experience. To investigate this phenomenon from a neuroscientific perspective while considering ketamine's sex-specific effects. Two...
The International Journal of Neuropsychopharmacology
June 6, 2025
Benjamin Spurny-Dworak, Thomas Liebe, Samantha Graf et al.
2 citations
The N-methyl-D-aspartate receptor antagonist ketamine has found broad application in the field of psychiatry. Due to its rapid antidepressant and anti-suicidal properties, it is used as a treatment for major depressive disorder. Furthermore, ketamine evokes dissociative and psychotropic states, which allows the modeling of schizophrenic symptoms. The thalamus, a main target for ketamine's...
Wiener klinische Wochenschrift
March 1, 2025
Pia Baldinger-Melich, Marie Spies, Ina Bozic et al.
5 citations
Modern electroconvulsive therapy (ECT) and the approval of nasal esketamine for clinical use have significantly improved the approach to treatment-resistant depression (TRD), which is defined as non-response to at least two different courses of antidepressants with verified adherence to treatment, adequate dosage, and duration of treatment. The goal of this literature review is to present the...
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
November 1, 2024
Samantha Graf, Gregor Dörl, Christian Milz et al.
2 citations
Ketamine exerts rapid antidepressant effects by enhancing neuroplasticity, particularly in the amygdala and hippocampus-regions involved in fear processing and learning. While the role of ketamine's dissociative effects in its antidepressant response is debated, anxiety experienced during infusion has been negatively correlated with treatment outcomes. In this single-blind, placebo-controlled...
International journal of psychiatry in clinical practice
2024
Marie Spies, Siegfried Kasper, Richard Frey et al.
Modern electroconvulsive therapy (ECT) and ketamine currently represent the most effective treatment options in depressed patients showing non-response to two or more trials of antidepressants. Recently, large sample head-to-head comparisons of intravenous ketamine versus ECT for treatment-resistant depression (TRD) have fuelled the debate on which therapy might be more effective. However, the...
Frontiers in Psychiatry
September 8, 2020
Leo R. Silberbauer, B. Spurny, P. Handschuh et al.
43 citations
Introduction Converging evidence suggests that ketamine elicits antidepressant effects via enhanced neuroplasticity precipitated by a surge of glutamate and modulation of GABA. Magnetic resonance spectroscopic imaging (MRSI) illustrates changes to cerebral glutamate and GABA immediately following ketamine administration during dissociation. However, few studies assess subacute changes in the...
Cerebral Cortex
September 6, 2018
Gregory M. James, Gregor Gryglewski, Thomas Vanicek et al.
16 citations
Parcellation of distinct areas in the cerebral cortex has a long history in neuroscience and is of great value for the study of brain function, specialization, and alterations in neuropsychiatric disorders. Analysis of cytoarchitectonical features has revealed their close association with molecular profiles based on protein density. This provides a rationale for the use of in vivo molecular...