Brain functional network correlates and predictors of the perioperative antidepressant effect of esketamine in breast cancer patients: a double-blind randomized controlled trial using resting-state fMRI and graph theory.
Huimin Zhu, Qingfeng Wei, Shuang Xu, Yunwei Sun, Xuesheng Liu, Jiajia Zhu, Yongqiang Yu
Transl Psychiatry March 6, 2026 DOI: 10.1038/s41398-026-03929-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Double-blind Peer reviewed |
|---|---|
| Population | Breast cancer patients |
| Intervention | Esketamine |
| Topics | Esketamine |
| Citations | 1 |
| Key findings | A single preoperative dose of esketamine reduced depressive symptoms in breast cancer patients 24 hours after surgery, an effect associated with and predicted by changes in brain functional connectivity and network properties. |
Abstract
Brain functional network correlates and predictors of the perioperative antidepressant effect of esketamine in breast cancer patients: a double-blind randomized controlled trial using resting-state fMRI and graph theory.