María Dolores Gutiérrez‐lópez

2 papers in the library · 44 citations · publishing 2010-2017

Papers

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3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) produces edema due to BBB disruption induced by MMP-9 activation in rat hippocampus.

Neuropharmacology March 16, 2017 Mercedes Pérez-Hernández, María Encarnación Fernández-Valle, Ana Rubio-Araiz et al.

The recreational drug of abuse, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier (BBB) integrity in rats through an early P2X7 receptor-mediated event which induces MMP-9 activity. Increased BBB permeability often causes plasma proteins and water to access cerebral tissue leading to vasogenic edema formation. The current study was performed to examine the effect of...

DOI: 10.1016/j.neuropharm.2017.03.019 Full text MDMA Blood-brain barrier Animals Rats +19

Evidence that MDMA (‘ecstasy’) increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain

Journal of Neurochemistry January 12, 2010 Elisa Torres, María Dolores Gutiérrez‐lópez, Érika Borcel et al. 44 citations

J. Neurochem. (2010) 10.1111/j.1471‐4159.2010.06578.x Abstract 3,4‐Methylenedioxymethamphetamine (MDMA, ‘ecstasy’) produces selective long‐lasting serotonergic neurotoxicity in rats. The drug also produces acute hyperthermia which modulates the severity of the neurotoxic response. In addition, MDMA produces signs of neuroinflammation reflected as microglial activation and an increase in the...

DOI: 10.1111/j.1471-4159.2010.06578.x MDMA Ecstasy Serotonergic Neurotoxicity +7