3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) produces edema due to BBB disruption induced by MMP-9 activation in rat hippocampus.
Neuropharmacology March 16, 2017 Mercedes Pérez-Hernández, María Encarnación Fernández-Valle, Ana Rubio-Araiz et al.
The recreational drug of abuse, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier (BBB) integrity in rats through an early P2X7 receptor-mediated event which induces MMP-9 activity. Increased BBB permeability often causes plasma proteins and water to access cerebral tissue leading to vasogenic edema formation. The current study was performed to examine the effect of...
DOI: 10.1016/j.neuropharm.2017.03.019 (opens in new tab)
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MDMA
Blood-brain barrier
Animals
Rats
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