IBRO Neuroscience Reports
October 1, 2023
Iker Bengoetxea de Tena, Jonatan Martínez‐Gardeazabal, Lorena Galera-López et al.
The mechanisms for encoding, storing and retrieving memories are abundant and complex. Among them, the protein kinase C (PKC) family of enzymes, and more specifically PKCɣ isoform, regulates important aspects of synaptic plasticity and memory. In addition, PKCɣ has been found to interact with cannabinoid receptors. In this study, we investigated the density and activity of cannabinoid receptors...
Biochemical Pharmacology
November 2018
V Salgado-Mendialdúa, J Aguirre-Plans, E Guney et al.
Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 (CB1) receptors. These receptors are strongly enriched in presynaptic terminals, where they modulate neurotransmitter release. We analyzed, through a proteomic screening of...
PLoS One
November 4, 2013
Alvaro Llorente‐berzal, Emma Puighermanal, Aurelijus Burokas et al.
43 citations
Ecstasy is a drug that is usually consumed by young people at the weekends and frequently, in combination with cannabis. In the present study we have investigated the long-term effects of administering increasing doses of delta-9-tetrahydrocannabinol [THC; 2.5, 5, 10 mg/kg; i.p.] from postnatal day (pnd) 28 to 45, alone and/or in conjunction with 3,4-methylenedioxymethamphetamine [MDMA; two...
Neuropsychopharmacology
June 2013
Emma Puighermanal, Arnau Busquets-García, Maria Gomis-Gonzalez et al.
The potential therapeutic benefits of cannabinoid compounds have raised interest in understanding the molecular mechanisms that underlie cannabinoid-mediated effects. We previously showed that the acute amnesic-like effects of delta9-tetrahydrocannabinol (THC) were prevented by the subchronic inhibition of the mammalian target of rapamycin (mTOR) pathway. In the present study, we assess the...
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
December 5, 2012
Emma Puighermanal, Arnau Busquets-García, Rafaël Maldonado et al.
Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of...