MODULATION OF CANNABINOID RECEPTORS AND PHOSPHOLIPIDS IN COGNITIVELY IMPAIRED MICE LACKING PKCƔ
Iker Bengoetxea de Tena, Jonatan Martínez‐Gardeazabal, Lorena Galera-López, Andrés Ozaita, Rafaël Maldonado, Rafael Rodríguez‐Puertas
IBRO Neuroscience Reports October 1, 2023 DOI: 10.1016/j.ibneur.2023.08.532 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational animal study Peer reviewed |
|---|---|
| Sample size | 21 |
| Population | Brains from PKCγ knock-out mice (n=9) and matched wild-type control mice (n=12) |
| Key findings | The text states that PKCγ regulates aspects of synaptic plasticity and memory and interacts with cannabinoid receptors, and that PKCγ knock-out mice show mild cognitive impairment. The study examined cannabinoid receptor density and activity and the lipidomic profile in these mice versus wild-type controls, but no results are reported in the available text. |
Abstract
The mechanisms for encoding, storing and retrieving memories are abundant and complex. Among them, the protein kinase C (PKC) family of enzymes, and more specifically PKCɣ isoform, regulates important aspects of synaptic plasticity and memory. In addition, PKCɣ has been found to interact with cannabinoid receptors. In this study, we investigated the density and activity of cannabinoid receptors and the lipidomic profile of PKCɣ knock-out mice, which show mild cognitive impairment. Brains from PKCɣ knock-out mice (n=9) and matched wild-type controls (n=12) were used.