Δ9-tetrahydrocannabinol modulates the proteasome system in the brain.
Biochemical Pharmacology November 2018 V Salgado-Mendialdúa, J Aguirre-Plans, E Guney et al.
Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 (CB1) receptors. These receptors are strongly enriched in presynaptic terminals, where they modulate neurotransmitter release. We analyzed, through a proteomic screening of...
DOI: 10.1016/j.bcp.2018.08.026 (opens in new tab)
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THC
Cannabinoid
Hippocampus
Proteasome
+2