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Fengju Bai

3 papers in the library · 288 citations · publishing 1999-2004

Papers

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The Role of Metabolism in 3,4-(±)-Methylenedioxyamphetamine and 3,4-(±)-Methylenedioxymethamphetamine (Ecstasy) toxicity

Therapeutic Drug Monitoring March 19, 2004 Terrence J. Monks, Douglas C. Jones, Fengju Bai et al. 123 citations

3,4-Methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are ring-substituted amphetamine derivatives with stimulant and hallucinogenic properties. The recreational use of these amphetamines, especially MDMA, is prevalent despite warnings of irreversible damage to the central nervous system. MDA and MDMA are primarily serotonergic neurotoxicants. Because (1)...

DOI: 10.1097/00007691-200404000-00008 (opens in new tab) MDMA Ecstasy Serotonergic Serotonin +8

Serotonergic Neurotoxicity of 3,4-(±)-Methylenedioxyamphetamine and 3,4-(±)-Methylendioxymethamphetamine (Ecstasy) Is Potentiated by Inhibition of γ-Glutamyl Transpeptidase

Chemical Research in Toxicology May 31, 2001 Fengju Bai, Douglas C. Jones, Serrine S. Lau et al. 56 citations

Reactive metabolites play an important role in 3,4-(+/-)-methylenedioxyamphetamine (MDA) and 3,4-(+/-)-methylenedioxymethamphetamine (MDMA; ecstasy)-mediated serotonergic neurotoxicity, although the specific identity of such metabolites remains unclear. 5-(Glutathion-S-yl)-alpha-methyldopamine (5-GSyl-alpha-MeDA) is a serotonergic neurotoxicant found in the bile of MDA-treated rats. The brain...

DOI: 10.1021/tx010011l (opens in new tab) Serotonergic Serotonin Glutathione Neurotoxicity +3

Glutathione and N-Acetylcysteine Conjugates of α-Methyldopamine Produce Serotonergic Neurotoxicity: Possible Role in Methylenedioxyamphetamine-Mediated Neurotoxicity

Chemical Research in Toxicology November 19, 1999 Fengju Bai, Serrine S. Lau, Terrence J. Monks 109 citations

Direct injection of either 3,4-(+/-)-methylenedioxymethamphetamine (MDMA) or 3,4-(+/-)-methylenedioxyamphetamine (MDA) into the brain fails to reproduce the serotonergic neurotoxicity seen following peripheral administration. The serotonergic neurotoxicity of MDA and MDMA therefore appears to be dependent upon the generation of a neurotoxic metabolite, or metabolites, the identity of which...

DOI: 10.1021/tx990084t (opens in new tab) MDMA Serotonergic Serotonin Neurotoxicity +5