Serotonergic neurotoxic metabolites of ecstasy identified in rat brain.
The Journal of pharmacology and experimental therapeutics April 2005 Douglas C Jones, Christine Duvauchelle, Aiko Ikegami et al.
The selective serotonergic neurotoxicity of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) depends on their systemic metabolism. We have recently shown that inhibition of brain endothelial cell gamma-glutamyl transpeptidase (gamma-GT) potentiates the neurotoxicity of both MDMA and MDA, indicating that metabolites that are substrates for this enzyme...