Canadian Journal of Chemistry
September 4, 2026
Anton Homon, Pavithra Prasad, Jaxon Laramie et al.
The recent resurgence in psychedelic research has increased demand for these molecules for clinical studies. Due to the differences between national regulations and considering the dominance of the American market and its continued prohibition of many such molecules, the commercial availability of many of these compounds remains poor. This has also inhibited research into developing scalable...
ChemRxiv
March 2, 2026
William Charles Hosie, Artem Pyrozhok, Massimo Filgiomeni et al.
Clinical trials of psychedelics have shown preliminary promise for the treatment of psychiatric conditions such as major depressive disorder, substance use disorder, and treatment resistant depression.The most common psychedelic administration routes explored so far include intravenous injection, heated vapor inhalation, or a simple buffered salt solution administered to the nasal cavity.Given...
ChemMedChem
February 25, 2026
Anton A. Homon, Jaxon Laramie, John J. Hayward et al.
Bufotenin (also spelt as bufotenine) and its methylated derivative, 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), are potent psychedelics that are found in many plants but also excreted by some species of toads. The compounds are regulated differently around the world, and although used in traditional medicine, 20th-century prohibition culture has slowed research into their utility for...
ChemRxiv
November 26, 2025
Anton A. Homon, P. V. Vara Prasad, Elham Pourian et al.
The recent resurgence in psychedelic research has increased demand for these molecules for clinical studies. Due to the differences between national regulations and considering the dominance of the American market and its continued prohibition of many such molecules, the commercial availability of many of these compounds remains poor. This has also inhibited research into developing scalable...
Borealis
November 20, 2025
Anton A. Homon, John F. Trant, Pavithra Prasad et al.
Raw NMR data for the title paper, ready for reprocessing. Also includes processed .mnova files of the spectra pre-processed for those using MNOVA software.
Advanced Therapeutics
October 5, 2025
William Charles Hosie, Abhinandan Banerjee, Mary A. Egbuta et al.
Abstract Nanoformulation is often used to improve the solubility and uptake of bioactives; however, it also protects sensitive bioactives from chemical decomposition. A class of biocompatible emulsifiers created by conjugating hemp protein with green tea polyphenols is reported. A simple pH‐assisted coupling protocol is employed to synthesize covalent and non‐covalent conjugates, which are then...
ChemRxiv
June 26, 2025
Anton A. Homon, Jaxon Laramie, John J. Hayward et al.
Bufotenin (also spelt as bufotenine) and its methylated derivative, 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) are potent psychedelics (although the activity of the former is attenuated due to its low propensity to cross the blood-brain-barrier) that are found in many plants but also excreted by specific species of toads. The compounds are regulated differently around the world, and although...
ChemRxiv
February 27, 2025
William Charles Hosie, Mary Augustina Egbuta, Kasra Razmkhah et al.
Nanoformulation is often used to improve the solubility and uptake of bioactives; however, it also protects sensitive bioactives from chemical decomposition. We report a class of biocompatible emulsifiers created by conjugating hemp protein with green tea polyphenols. A simple pH-assisted coupling protocol was employed to synthesize covalent and non-covalent conjugates, which were then used to...
Cannabis and Cannabinoid Research
August 9, 2023
Abhinandan Banerjee, William Hosie, Ana Carolina Terso Ventura et al.
Background: This article highlights the formulation of a solid Δ9-tetrahydrocannabinol (THC)-loaded ingestible prepared from pure THC distillate. Methods: A THC-containing ethanol-assisted cannabinoid nanoemulsion (EACNE) was created using a solvent displacement technique. Subsequently, the EACNE was converted to a solid powdery material while still retaining its THC potency, a format uniquely...
Abhinandan Banerjee, William Hosie, Ana Carolina Terso Ventura et al.
Background: This paper highlights the formulation of a solid THC-loaded ingestible prepared from pure THC distillate. A THC ethanol-assisted cannabinoid nanoemulsion (EACNE) was created without the need for specialized emulsification equipment such as a high-pressure homogenizer or a microfluidizer. Stress-testing was performed on the EACNE to evaluate its chemical and colloidal stability under...