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William Charles Hosie

3 papers in the library · publishing 2025-2026

Papers

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Self-nanoemulsifying drug delivery systems (SNEDDS) as psychotherapeutic couriers

ChemRxiv March 2, 2026 William Charles Hosie, Artem Pyrozhok, Massimo Filgiomeni et al.

Clinical trials of psychedelics have shown preliminary promise for the treatment of psychiatric conditions such as major depressive disorder, substance use disorder, and treatment resistant depression.The most common psychedelic administration routes explored so far include intravenous injection, heated vapor inhalation, or a simple buffered salt solution administered to the nasal cavity.Given...

Hemp Proteins Conjugated with Green Tea Polyphenol Extract Form De Novo Plant‐Sourced Emulsifiers Suitable for Nanodelivery Systems Bearing Lipophilic Psychopharmaceuticals

Advanced Therapeutics October 5, 2025 William Charles Hosie, Abhinandan Banerjee, Mary A. Egbuta et al.

Abstract Nanoformulation is often used to improve the solubility and uptake of bioactives; however, it also protects sensitive bioactives from chemical decomposition. A class of biocompatible emulsifiers created by conjugating hemp protein with green tea polyphenols is reported. A simple pH‐assisted coupling protocol is employed to synthesize covalent and non‐covalent conjugates, which are then...

Hemp proteins conjugated with green tea polyphenol extract form de novo plant-sourced emulsifiers suitable for nanodelivery systems bearing lipophilic psychopharmaceuticals

ChemRxiv February 27, 2025 William Charles Hosie, Mary Augustina Egbuta, Kasra Razmkhah et al.

Nanoformulation is often used to improve the solubility and uptake of bioactives; however, it also protects sensitive bioactives from chemical decomposition. We report a class of biocompatible emulsifiers created by conjugating hemp protein with green tea polyphenols. A simple pH-assisted coupling protocol was employed to synthesize covalent and non-covalent conjugates, which were then used to...