Dg Grahame‐smith

Increased platelet membrane [3H]‐LSD binding in patients on chronic neuroleptic treatment.

British Journal of Clinical Pharmacology April 1, 1985 Michael Schächter, David P. Geaney, Dg Grahame‐smith et al. 20 citations

Using a [3H]‐lysergic acid diethylamide [(3H]‐LSD) binding technique, platelet 5‐hydroxytryptamine (5‐HT) receptor number and affinity were compared in schizophrenics treated with depot thioxanthenes and phenothiazines and controls. There was an approximately 30% increase in platelet receptor number (Bmax) in the patient group. There was a decrease in affinity (increase in Kd) of about 30% in...