Pharmacological and behavioral components of tolerance to LSD and mescaline in rats
Pharmacology Biochemistry and Behavior September 1, 1977 Thomas F. Murray, Arthur L. Craigmill, Guenther Fischer 11 citations
A fixed-ratio schedule of water reinforcement (FR-10) was used to examine the relative contributions of pharmacological and behavioral mechanisms in the development of tolerance to the disruptive effects of LSD and mescaline in the rat. Rats treated daily with LSD or mescaline before operant testing developed tolerance to the impairement of responding, while rats treated daily after each...