Karen Thatcher

Identification of a possible role for atrial natriuretic peptide in MDMA-induced hyperthermia.

Toxicology Letters October 10, 2011 Sandra L Hrometz, Karen Thatcher, Jeremy A Ebert et al.

MDMA (3,4-methylenedioxymethamphetamine) induces thermogenesis in a mitochondrial uncoupling protein 3-dependent manner. There is evidence that this hyperthermia is mediated in part by the lipolytic release of free fatty acids, that subsequently activate uncoupling protein 3 in skeletal muscle mitochondria. We hypothesize that atrial natriuretic peptide (ANP), a strong lipolytic mediator, may...