Identification of a possible role for atrial natriuretic peptide in MDMA-induced hyperthermia.
Sandra L Hrometz, Karen Thatcher, Jeremy A Ebert, Edward Mills, Jon E. Sprague
Toxicology Letters October 10, 2011 DOI: 10.1016/j.toxlet.2011.07.025 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Sample size | 16 |
| Population | Male Sprague-Dawley rats |
| Interventions | MDMA Anantin |
| Dose | MDMA 40 mg/kg, sc; Anantin 40 mg, ip |
| Duration | ANP measured at baseline, 10, 20, 30, and 60 min after MDMA; Anantin given 15 min before and after MDMA |
| Measures | plasma ANP levels, body temperature |
| Topics | MDMA |
| Key findings | MDMA administration produced a rapid rise in plasma atrial natriuretic peptide (ANP) within 10 minutes, and blocking ANP receptors with Anantin significantly attenuated MDMA-induced hyperthermia, suggesting ANP signaling contributes to the temperature increase. |
Abstract
MDMA (3,4-methylenedioxymethamphetamine) induces thermogenesis in a mitochondrial uncoupling protein 3-dependent manner. There is evidence that this hyperthermia is mediated in part by the lipolytic release of free fatty acids, that subsequently activate uncoupling protein 3 in skeletal muscle mitochondria. We hypothesize that atrial natriuretic peptide (ANP), a strong lipolytic mediator, may contribute to the induction and maintenance of MDMA-induced thermogenesis. The specific aims of this study were to (1) determine if ANP is released following MDMA administration, and (2) use the ANP receptor antagonist, Anantin, to ascertain the role of ANP in MDMA-induced hyperthermia. ANP levels were measured in plasma at baseline, 10, 20, 30 and 60 min following MDMA (40 mg/kg, sc) administration in 16 male Sprague-Dawley rats. A robust increase in ANP was seen within 10 min of MDMA administration. ANP levels returned to baseline at 20 min and then gradually rose over the 60 min monitoring period. The administration of Anantin (40 mg, ip), 15 min before and after MDMA, significantly attenuated the MDMA-induced hyperthermia. We conclude that ANP signaling contributes to the hyperthermia induced by MDMA.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cites 4
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- Influence of dietary fats on Ecstasy-induced hyperthermia. British Journal of Pharmacology May 29, 2007