Jin Tae Hong

2 papers in the library · 5 citations · publishing 2023

Papers

Prenatal ketamine exposure impairs prepulse inhibition via arginine vasopressin receptor 1A-mediated GABAergic neuronal dysfunction in the striatum.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie April 1, 2023 Aeseul Kim, Sun Mi Gu, Haemiru Lee et al. 5 citations

Prenatal exposure to NMDA receptor antagonists like ketamine and methoxetamine in pregnant rats leads to psychosis-like behaviors in their offspring, including hyperactivity and reduced prepulse inhibition (PPI), a measure of sensorimotor gating. These effects are linked to increased expression of the arginine vasopressin receptor 1A (Avpr1a) in the striatum, and artificially overexpressing Avpr1a in the striatum also impairs PPI. Additionally, the treatments raise levels of glutamate decarboxylase 67 (GAD67) and GABA in the striatum, indicating that prenatal NMDA receptor blockade disrupts GABAergic neuron function and sensorimotor gating through Avpr1a regulation.

DOI: 10.1016/j.biopha.2023.114318 Full text Methoxetamine N-methyl-d-aspartate receptor Prepulse inhibition Δ-aminobutyric acid

Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie November 8, 2023 Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong et al.

In mice, 18 abused drugs (including cocaine, methamphetamine, and several synthetic cannabinoids and cathinones) were tested using intracranial self-stimulation (ICSS) of the medial forebrain bundle to assess their reward-seeking potential. Dopamine transporter (DAT) availability in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) significantly correlated with the ICSS threshold after drug treatment. Extracellular dopamine and calcium levels in PC-12 cells also correlated with the ICSS threshold. The findings suggest that drug-induced reward-seeking behavior may be linked to DAT availability-mediated extracellular dopamine levels in the mPFC and NAc.

DOI: 10.1016/j.biopha.2023.115860 Full text Medicine Psychology