Water research
December 1, 2025
Yasar Arafath Sharfudeen, Minjin Kim, Donghyun Kim et al.
Wastewater-based epidemiology (WBE) is increasingly used as a complementary tool for monitoring drug use at the population level, providing anonymized, real-time estimates of community drug consumption. Site-specific applications of WBE can identify localized patterns that national or municipal surveys may overlook. This study presents the first comprehensive, site-specific assessment of...
The Science of the total environment
November 15, 2024
Ha Hyun Lim, Hye Jin Cha, Jeong-Eun Oh
7 citations
22 illicit drugs were monitored in Seoul, the capital of South Korea for 21 days using wastewater-based epidemiology to assess the drug usage patterns for the first time by region and social status. Among the targeted compounds, 10 were detected, with consistent detection of methamphetamine in samples over the entire sampling period. In addition, ketamine had the highest estimated consumption...
Journal of veterinary science
September 1, 2024
Sun Mi Gu, Eunchong Hong, Sowoon Seo et al.
1 citation
Glutamic acid decarboxylase 67 (GAD67) is a gamma-aminobutyric acid (GABA) synthesis enzyme associated with the function of other neurotransmitter receptors, such as the N-methyl-D-aspartate (NMDA) receptor and cannabinoid receptor 1. However, the role of GAD67 in the development of different abused drug-induced reward behaviors remains unknown. In order to elucidate the mechanisms of substance...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
April 1, 2023
Aeseul Kim, Sun Mi Gu, Haemiru Lee et al.
5 citations
Ketamine is a widely used anesthetic with N-methyl-D-aspartate (NMDA) receptor antagonism. Exposure to ketamine and NMDA receptor antagonists may induce psychosis. However, the mechanism underlying the effects of ketamine on the immature brain remains unclear. In this study, NMDA receptor antagonists, ketamine and methoxetamine, were administered to pregnant F344 rats (E17). These regimens...
Toxicology Letters
November 1, 2021
K. S. Yoon, Hye Jin Cha, S. Choi et al.
Two new psychoactive substances (NPSs) classified as phenethylamines, namely 2-((2-(4-Iodo-2,5-dimethoxyphenyl)ethylamino)methyl)phenol (25I-NBOH) and 2-(((2-(4-chloro-2,5-dimethoxyphenyl)ethyl)amino)methyl)phenol (25C-NBOH), are being abused by people seeking recreational hallucinogens. These NPSs may cause serious health problems as their adverse effects are not known in most cases....
Drug and chemical toxicology (New York, N.Y. 1978)
June 29, 2020
K. S. Yoon, Sun Mi Gu, Hye Jin Cha et al.
Abstract Abuse of new psychoactive substances is an emerging social problem. Several phenethylamines are internationally controlled substances as they are likely to be abused and have adverse effects. Phenethylamine analog 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe) has been reported as one of the most commonly abused psychoactive substance. However, the...
Toxicology Letters
November 6, 2019
K. S. Yoon, Jin-Moo Lee, Young-Hoon Kim et al.
Two synthetic tryptamines, namely [3-[2-(diethylamino)ethyl]-1H-indol-4-yl] acetate (4-AcO-DET) and 3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-ol (4-HO-MET), are abused by individuals seeking recreational hallucinogens. These new psychoactive substances (NPSs) can cause serious health problems because their adverse effects are mostly unknown. In the present study, we evaluated the...
Toxicology Letters
April 1, 2019
K. S. Yoon, Jaesuk Yun, Young-Hoon Kim et al.
Two emerging psychoactive substances, 2-(2,5-dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe) and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine (25C-NBOMe), are being abused, leading to fatal and non-fatal intoxications. However, most of their adverse effects have been reported anecdotally. In the present study, cardiotoxicity was evaluated through...